What is this information about?
This information tells you about the different kinds of anti-hormone therapies that you can take. These depend on whether you have reached the menopause (either naturally or because of your treatment) or not. You will find out here about:
- what these medicines are called and how they work
- what your options are if you have not reached the menopause but want to take this medicine
- any side-effects of these medicines and how you can cope with them.
Why have I been given this information?
You have been given this information because your cancer can be treated with medicines called anti-hormone therapies that block or decrease the hormones that your body makes. This information will help you decide if you want to take this medicine.
Feeling confident about your body and being able to make informed decisions about your health is an important part of being well. We want you to feel in control of your health and your ability to manage it. The symptoms diary included here will help you with this. We understand that this is a difficult time when you have finished your treatment. We are here to support you with any symptoms or side-effects that you have. Please remember that you are not alone.
What is anti-hormone therapy?
Anti-hormone therapy is also called endocrine therapy. It is a treatment for breast cancers that are using your body’s hormones to grow.
It works by blocking hormones from attaching to cancer cells. Or, by decreasing the body’s production of hormones.
Anti-hormone therapies can also be used to treat ductal carcinoma in situ (DCIS). Anti-hormone therapies also reduce the risk of breast cancer in women with a strong family history of breast cancer, or other risk factors for breast cancer.
Why is anti-hormone therapy recommended?
Anti-hormone therapy is recommended because:
- it lowers the chance of cancer coming back
- it lowers the risk of cancer developing in the other breast
- it can slow or stop the growth of cancer that has spread
- it can reduce the size of a tumour before surgery.
How does anti-hormone therapy work?
Anti-hormone therapy works by either:
- blocking the oestrogen attaching to the hormone receptors in the breast cells or
- reducing the production of oestrogen hormone (these medicines are called Aromatase Inhibitors).
Oestrogens are a group of hormones that are important for women’s all-round health. This includes puberty, menstruation (periods), pregnancy and menopause (when periods stop).
How do medicines that block hormones from attaching to cancer cells work?
Image reproduced with permission from Owise.
This medicine works by stopping the hormones from attaching to the receptors on the cancer cells.
When the hormones cannot get to the cancer cells, the tumour growth may slow, and the cells may die. If you think of the hormones as a food source for the cancer cells, when the food source is cut off, the cancer cells starve and die.
What are the brand names of the medicines that block hormones from attaching to cancer cells?
These medicines are called SERMs (Selective estrogen receptor modulators).
- Tamoxifen. It is usually taken daily in pill form. It is often used to reduce the risk of cancer coming back in pre-menopausal women who have been treated for early-stage breast cancer. In this situation, it is typically taken for five to seven years.
Tamoxifen may also be used to treat advanced cancer or if you are post-menopausal (you have reached menopause).
- Fulvestrant (Faslodex). Fulvestrant is given as an injection every two weeks for the first month, then once a month after this. It is given to post-menopausal women to treat advanced breast cancer.
How do medicines that reduce the amount of oestrogen production (aromatase inhibitors) work?
Aromatase inhibitors (AIs) are another type of anti-hormone treatment. They reduce the amount of hormones production in your body. This means that breast cancer cells will not get the hormones that they need to grow.
If you are post-menopausal, either naturally or because of treatment, you may be prescribed aromatase inhibitors.
What are the brand names of aromatase inhibitors?
- Letrozole (also known as Femara). Letrozole is a non-steroidal AI. It is used to reduce the risk of cancer coming back in women who have been treated for early-stage breast cancer. It can be used alone or given after completing tamoxifen treatment. Letrozole is also used to treat advanced breast cancer.
- Exemestane (also known as Aromasin). Exemestane is a steroidal AI. It is used to reduce the risk of cancer coming back in women who have been treated for early-stage breast cancer. It can also be used to treat advanced breast cancer in women if tamoxifen is no longer working.
- Anastrozole (also known as Arimidex). Anastrozole is a non-steroidal AI. It is used to reduce the risk of cancer coming back in women who have been treated for early-stage breast cancer. It can also be used to treat advanced breast cancer.
How long will I have to take aromatase inhibitors?
How long you take aromatase inhibitors depends on your specific situation.
Research shows us that usually people take these medicines for up to seven years, but every person is different. You and your doctor will decide together how long you should take them.
If I haven’t reached menopause yet (I am pre-menopausal), can I get treatment to stop my ovaries from making hormones?
Yes. If you haven’t reached menopause, you may choose to have treatment that will stop your ovaries producing hormones.
These options include:
- Medicine, such as Goserelin (Zoladex)
- Surgery to remove the ovaries (oophorectomy)
When you stop taking Zoladex, your ovaries can make hormones again.
What are the side-effects of anti-hormone therapy?
All the hormonal therapies described here reduce the levels of oestrogen in your body.
However, they all have some side effects. This means that they can all cause symptoms of menopause like hot flushes, mood swings, vaginal symptoms and a change in sex drive.
The range and severity of menopausal symptoms vary from one woman to another. Some women may experience very few menopausal symptoms.
Symptoms will usually become less noticeable with time, as your body adjusts to lower oestrogen levels.
In general, hormone replacement therapy is not recommended in women who have had hormone positive breast cancer but there are other things that can help.
What can help me manage the side effects of anti-hormone therapies?
Many people find the side effects of hormone therapy difficult to cope with.
If the side effects are stopping you taking your hormone therapy, talk with your cancer specialist before making any decisions to stop it. They may suggest a short break from treatment to see if the side effects improve.
If you have on-going side effects from hormone therapy, talk to your cancer specialist so they can discuss with you the best way to manage them.
There are ways to improve your symptoms. Occasionally, your cancer specialist may suggest you try a different therapy.
The most common side effects and ways to manage them
| Symptoms | Possible solutions | |
| 1 | Hot flushes and night Sweats | Reduce caffeine, alcohol, smoking. Drugs that may help: Gabapentin, Venlafaxine, Escitalopram, Citalopram |
| 2 | Mood changes and reduced sex drive | Cognitive behavioural therapy, GP, Psychological Therapies to help with managing relationships |
| 3 | Vaginal dryness or irritation | Vaginal moisturizers, such as Replens MD, Senselle or Hyalofemme, provide long-term relief |
| 4 | Fatigue | Physical activity, counselling, cognitive behavioural therapy, massage & relaxation, Reiki |
| 5 | Headaches and nausea | Medications, cognitive behavioural therapy, non-medicinal remedies |
| 6 | Joint and muscle pain | Medication: Duloxetine, physical activity, acupuncture, maintenance of body weight |
| 7 | Blood clots in veins | Physical activity. Look out for signs and symptoms of DVT (deep vein thrombosis). |
| 8 | Endometrial cancer or uterine cancer | Regular monitoring for any abnormal signs/symptoms |
| 9 | Osteoporosis and effects on bone density | Calcium/Vitamin D supplements and nutritional intake, healthy eating, healthy weight, physical activity, dexa scans |
| 10 | Sleep disturbances | Physical activity, healthy eating, managing stress, maintaining healthy relationships and being socially active. Intellectual stimulation, cognitive behavioural therapy |
Why do I need to keep a symptom diary?
We have included a symptom diary for you to keep track of your symptoms. This will help you to be in control of managing your symptoms.
Keep this diary for the first 12 to 20 weeks of your treatment. It will help you and your specialist team to decide what medicines will give you the best quality of life with the hormone therapy.
| DATE | SYMPTOM | FREQUENCY | MANAGED WITH | OUTCOME |
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Notes: (space to write in notes)
Who can I speak to for more information and advice?
If you would like more information about hormone treatment, ask your surgeon, cancer specialist (oncologist), breast care nurse or other health professional.
Useful contacts and websites
Breast Care Unit Helpline
01273 696955
Ext. 64111
Breast Care Team Email
Breast Cancer Now
Triage Sheet
Physical activity guidelines for adults and older adults
From Gov.UK
This leaflet is intended for patients receiving care in Brighton.
The information in this leaflet is for guidance purposes only and is in no way intended to replace professional clinical advice by a qualified practitioner