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Information for patients and carers
On this page
- What is this information about?
- Why have I been given this information?
- What is Penthrox?
- Is Penthrox safe for my child?
- Why is Penthrox a good medicine for my child to have for pain relief in hospital?
- Are there any things that mean Penthrox may not be right for my child (contraindications to using Penthrox)?
- Do
- How can I help my child to use their Penthrox inhaler?
- What side effects might my child get from using the Penthrox inhaler?
- Where can I get further information about Penthrox if I need it after I have read this information?
What is this information about?
This information is about Penthrox pain relief medicine. It explains:
- what Penthrox is
- why Penthrox is the right medicine to give your child to relieve their pain
- when Penthrox should not be used
- how to help your child use their Penthrox
- the side effects that Penthrox may have.
Why have I been given this information?
You have been given this information because your child has a painful injury or needs a medical procedure which could be painful for them to have without pain relief. Your child’s healthcare professional thinks that Penthrox is the right pain-relief medicine for them to have.
Reading this information can:
- help you to know what to expect when your child has Penthrox
- make sure your child is safe and has good pain relief when they take Penthrox.
What is Penthrox?
Penthrox is a strong pain-relieving medicine. It is a vapour (tiny droplets in air) that your child breathes in (inhales) through a small handheld device (inhaler). This is often called the ‘green whistle’.

The vapour in the Penthrox inhaler contains a medicine called methoxyflurane. In the past this has been used as an anaesthetic for operations. When it is used for this, it is at much higher doses than there are in the Penthrox inhaler.
Is Penthrox safe for my child?
Your child gets a very small, safe, dose of methoxyflurane when they use a Penthrox inhaler for pain relief.
Penthrox:
- is not yet licensed for use in children in the UK but
- it has been used safely and widely in children in other countries (such as Australia) for over 30 years.
As well as UHSx, some other hospitals in the UK are also starting to use it in children. We have no reason to believe that Penthrox is unsafe for children.
Why is Penthrox a good medicine for my child to have for pain relief in hospital?
Penthrox:
- provides fast and effective pain relief
- lets your child control their inhaler and use it as needed
- means your child is less likely to need injections or other pain medicines.
Are there any things that mean Penthrox may not be right for my child (contraindications to using Penthrox)?
Penthrox may not be right for your child if they:
- have had a bad reaction to anaesthetic medicines in the past
- have liver, kidney or heart problems which are not minor
- take certain medicines that affect the liver or kidneys
- have a close family member who has had a condition called malignant hyperthermia.
Do
- tell your child’s doctor or nurse about any medical conditions your child has and any medicines they are taking.
How can I help my child to use their Penthrox inhaler?
A member of staff will show your child how to use their inhaler.
- Do make sure that your child holds and uses the inhaler themselves.
- They should breathe in and out through the whistle. This helps to prevent the vapour escaping into the air.
- The vapour has a strong fruity taste. It may cause your child to cough when they first breathe it in.
- Pain relief usually begins within a few breaths. Your child can continue using it as needed.
Be aware,
if your child needs to have a painful procedure, they may need to use the inhaler often or nearly all the time while we do it. This will give them stronger pain relief.
What side effects might my child get from using the Penthrox inhaler?
Like all medicines, Penthrox can have side effects. Some of the more usual side effects of Penthrox include
feeling:
- dizzy
- drowsy
- sick
having:
- a headache
- coughing
- double vision
- flushed and itchy skin.
If your child becomes very drowsy, they will be unable to inhale the vapour. This means that they will soon stop being so drowsy as the medicine wears off very quickly.
Serious side effects are very rare but can include:
- allergic reactions
- liver or kidney problems.
Be aware,
if your child becomes unwell after using Penthrox, please return to hospital. Tell staff that your child has used Penthrox.
Where can I get further information about Penthrox if I need it after I have read this information?
Please ask a member of your child’s A&E healthcare team.
The information in this leaflet is for guidance purposes only and is in no way intended to replace professional clinical advice by a qualified practitioner.
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